Phosphodiesterase-5 inhibitors for the treatment of secondary Raynaud’s phenomenon: systematic review and meta-analysis of randomised trials — Roustit et al. 72 (10): 1696 — Annals of the Rheumatic Diseases

PDE-5 inhibitors appear to have significant but moderate efficacy in secondary RP. A further large RCT is needed.

via Phosphodiesterase-5 inhibitors for the treatment of secondary Raynaud’s phenomenon: systematic review and meta-analysis of randomised trials — Roustit et al. 72 (10): 1696 — Annals of the Rheumatic Diseases.

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Access : A Randomized, Double-Blind, Controlled Trial Comparing Rifaximin Plus Lactulose With Lactulose Alone in Treatment of Overt Hepatic Encephalopathy : The American Journal of Gastroenterology

Combination of lactulose plus rifaximin is more effective than lactulose alone in the treatment of overt HE.

via Access : A Randomized, Double-Blind, Controlled Trial Comparing Rifaximin Plus Lactulose With Lactulose Alone in Treatment of Overt Hepatic Encephalopathy : The American Journal of Gastroenterology.

Current and new oral antithrombotics in non-valvular atrial fibrillation: a network meta-analysis of 79 808 patients — Dogliotti et al. — Heart

In this network meta-analysis, novel oral anticoagulants were the most promising treatments to reduce stroke, stroke or systemic embolism, and all-cause mortality in patients with AF.

via Current and new oral antithrombotics in non-valvular atrial fibrillation: a network meta-analysis of 79 808 patients — Dogliotti et al. — Heart.

Angiotensin-Converting Enzyme Inhibitors and Alzheimer’s Disease Progression in Older Adults: Results from the Réseau sur la Maladie d’Alzheimer Français Cohort – Soto – 2013 – Journal of the American Geriatrics Society – Wiley Online Library

The use of ACE-Is in older adults with AD is associated with a slower rate of cognitive decline independent of hypertension. Future research is needed to explore the role of ACE-Is in long-term AD progression.

via Angiotensin-Converting Enzyme Inhibitors and Alzheimer’s Disease Progression in Older Adults: Results from the Réseau sur la Maladie d’Alzheimer Français Cohort – Soto – 2013 – Journal of the American Geriatrics Society – Wiley Online Library.

What Analgesics Do Older People Use Prior to Initiating Oxycodone for Non-Cancer Pain? A Retrospective Database Study – Online First – Springer

Oxycodone is frequently initiated for non-cancer pain without first trialing other analgesics. This highlights the need for prescribing practices to be reviewed in light of increasing concerns about adverse drugs events and death due to oxycodone, particularly in older people.

via What Analgesics Do Older People Use Prior to Initiating Oxycodone for Non-Cancer Pain? A Retrospective Database Study – Online First – Springer.

Long-acting bronchodilators improve Health Related Quality of Life in patients with COPD

The data coming from the review support the efficacy of long acting bronchodilators in improving HRQoL/HS of COPD patients. Further research evaluating HRQoL/HS as primary outcome and according to guidelines on Patient Reported Outcomes is needed.

via Long-acting bronchodilators improve Health Related Quality of Life in patients with COPD.

The use of cholinesterase inhibitors and the risk of myocardial infarction and death: a nationwide cohort study in subjects with Alzheimer’s disease

Cholinesterase inhibitor use was associated with a reduced risk of MI and death in a nationwide cohort of subjects diagnosed with Alzheimer’s dementia. These associations were stronger with increasing ChEI dose.

via The use of cholinesterase inhibitors and the risk of myocardial infarction and death: a nationwide cohort study in subjects with Alzheimer’s disease.

Reduction of Cancer-Related Fatigue With Dexamethasone: A Double-Blind, Randomized, Placebo-Controlled Trial in Patients With Advanced Cancer

Conclusion Dexamethasone is more effective than placebo in improving CRF and quality of life in patients with advanced cancer.

via Reduction of Cancer-Related Fatigue With Dexamethasone: A Double-Blind, Randomized, Placebo-Controlled Trial in Patients With Advanced Cancer.

BMC Pulmonary Medicine | Abstract | A rapid and efficient way to manage hyponatremia in patients with SIADH and small cell lung cancer: treatment with tolvaptan

Based on this algorithm all patients started chemotherapy in time. Subsequently, the treatment with tolvaptan lead to an improvement of the ECOG-performance status. In addition, all patients benefit from the effective management of SIADH which omitted prolonged hospital stays and non-elective hospitalizations due to an unstable clinical condition due to severe hyponatremia. These observations add new insight to management of SIADH in thoracic oncology and are of interest for specialists in oncology, endocrinology and pulmonary medicine.

via BMC Pulmonary Medicine | Abstract | A rapid and efficient way to manage hyponatremia in patients with SIADH and small cell lung cancer: treatment with tolvaptan.

Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials : The Lancet

The vascular risks of high-dose diclofenac, and possibly ibuprofen, are comparable to coxibs, whereas high-dose naproxen is associated with less vascular risk than other NSAIDs. Although NSAIDs increase vascular and gastrointestinal risks, the size of these risks can be predicted, which could help guide clinical decision making.

via Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials : The Lancet.