Navigating High Risk Procedures with More than Just a Street Map | Abstract

Navigating High Risk Procedures with More than Just a Street Map | Abstract.

Comparison of peripherally inserted central venous catheters (PICC) versus subcutaneously implanted port-chamber catheters by complication and cost for patients receiving chemotherapy for non-haematological malignancies – Online First – Springer

Port devices are associated with a lower risk of complications, with no difference in cost, compared to PICC lines in patients with non-haematological malignancies receiving intravenous chemotherapy.

via Comparison of peripherally inserted central venous catheters (PICC) versus subcutaneously implanted port-chamber catheters by complication and cost for patients receiving chemotherapy for non-haematological malignancies – Online First – Springer.

Contraindicated Use of Bevacizumab and Toxicity in Elderly Patients With Cancer

Conclusion Our study demonstrates widespread use of bevacizumab among patients who had contraindications. Black patients were less likely to receive the drug, but those who did were more likely to have a contraindication. Efforts to understand toxicity and efficacy in populations excluded from clinical trials are needed.

via Contraindicated Use of Bevacizumab and Toxicity in Elderly Patients With Cancer.

The use of cholinesterase inhibitors and the risk of myocardial infarction and death: a nationwide cohort study in subjects with Alzheimer’s disease

Cholinesterase inhibitor use was associated with a reduced risk of MI and death in a nationwide cohort of subjects diagnosed with Alzheimer’s dementia. These associations were stronger with increasing ChEI dose.

via The use of cholinesterase inhibitors and the risk of myocardial infarction and death: a nationwide cohort study in subjects with Alzheimer’s disease.

Kidney International – No difference in bleeding risk between subcutaneous enoxaparin and heparin for thromboprophylaxis in end-stage renal disease

Thus, in dialysis patients, daily enoxaparin for thromboprophylaxis was not associated with increased serious bleeding or less effective compared to subcutaneous heparin.

via Kidney International – No difference in bleeding risk between subcutaneous enoxaparin and heparin for thromboprophylaxis in end-stage renal disease.

Cancer Screening in Persons With Dementia. Just Stop It. Please. | GeriPal – Geriatrics and Palliative Care Blog

Cancer Screening is of little benefit in persons with dementia but can cause very serious harms.   Older persons with dementia have limited life expectancies which makes any benefit from cancer screening very unlikely.  This is because cancer screening works by identifying a cancer many years (generally at least 5-10 years) before it would threaten health.

via Cancer Screening in Persons With Dementia. Just Stop It. Please. | GeriPal – Geriatrics and Palliative Care Blog.

High Procedure Volume Is Strongly Associated With Improved Survival After Lung Cancer Surgery

Conclusion High-volume hospitals have higher resection rates and perform surgery among patients who are older, have lower socioeconomic status, and have more comorbidities; despite this, they achieve better survival, most notably in the early postoperative period.

via High Procedure Volume Is Strongly Associated With Improved Survival After Lung Cancer Surgery.

Safety and Efficacy of Daptomycin as First-Line Treatment for Complicated Skin and Soft Tissue Infections in Elderly Patients: An Open-Label, Multicentre, Randomized Phase IIIb Trial – Online First – Springer

In elderly patients, for whom data were previously limited, the efficacy and safety of daptomycin have been confirmed, including for infections caused by S. aureus, regardless of methicillin susceptibility.

via Safety and Efficacy of Daptomycin as First-Line Treatment for Complicated Skin and Soft Tissue Infections in Elderly Patients: An Open-Label, Multicentre, Randomized Phase IIIb Trial – Online First – Springer.

Atrial Fibrillation in CKD: Balancing the Risks and Benefits of Anticoagulation

Current recommendations for anticoagulation in patients treated with dialysis and those with an earlier stage of CKD are based on clinical trials in the general atrial fibrillation population that have largely excluded individuals with CKD. Observational studies of anticoagulation in dialysis patients have produced conflicting results, mainly because of increased risk of bleeding.

via Atrial Fibrillation in CKD: Balancing the Risks and Benefits of Anticoagulation.

Abusive Prescribing of Controlled Substances — A Pharmacy View — NEJM

Pharmacies have a role to play in the oversight of prescriptions for controlled substances, and opioid analgesics in particular. Under the Controlled Substances Act, pharmacists must evaluate patients to ensure the appropriateness of any controlled-substance prescription.

via Abusive Prescribing of Controlled Substances — A Pharmacy View — NEJM.