Access : The Relation Between Symptom Improvement and Gastric Emptying in the Treatment of Diabetic and Idiopathic Gastroparesis : The American Journal of Gastroenterology

In this review, no evidence of a relationship between SI and GE was identified for different drugs used for the treatment of gastroparesis. This finding questions the use of GE measurement to direct drug development for gastroparesis.

via Access : The Relation Between Symptom Improvement and Gastric Emptying in the Treatment of Diabetic and Idiopathic Gastroparesis : The American Journal of Gastroenterology.

Advertisements

Pain Medicine News – Management of Opioid-Induced Constipation in Patients With Advanced Illness

This Special Report discusses the management of OIC in patients with advanced illness, including RELISTOR (methylnaltrexone bromide), a second-line therapeutic option that inhibits opioids from binding to target receptors within the GI tract and does not cross the blood-brain barrier.

via Pain Medicine News – Management of Opioid-Induced Constipation in Patients With Advanced Illness.

Reduction of Cancer-Related Fatigue With Dexamethasone: A Double-Blind, Randomized, Placebo-Controlled Trial in Patients With Advanced Cancer

Conclusion Dexamethasone is more effective than placebo in improving CRF and quality of life in patients with advanced cancer.

via Reduction of Cancer-Related Fatigue With Dexamethasone: A Double-Blind, Randomized, Placebo-Controlled Trial in Patients With Advanced Cancer.

The Burden of Urinary Incontinence and Urinary Bother Among Elderly Prostate Cancer Survivors

Compared with their peers without PCa, elderly PCa survivors had a two-fold to five-fold greater prevalence of urinary incontinence, which rose with increasing survivorship duration. Observation, surgery, and ADT were each associated with increased urinary bother. These data suggest a substantially greater burden of urinary health problems among elderly PCa survivors than previously recognized.

via The Burden of Urinary Incontinence and Urinary Bother Among Elderly Prostate Cancer Survivors.

Outcomes and xerostomia after postoperative radiotherapy for oral and oropharyngeal carcinoma – Wang – Head & Neck – Wiley Online Library

Outcomes and xerostomia after postoperative radiotherapy for oral and oropharyngeal carcinoma – Wang – Head & Neck – Wiley Online Library.

Optimal control of nausea and vomiting with a three-drug antiemetic regimen with aprepitant in metastatic pancreatic cancer patients treated with first-line modified FOLFIRINOX – Online First – Springer

Optimal control of nausea and vomiting with a three-drug antiemetic regimen with aprepitant in metastatic pancreatic cancer patients treated with first-line modified FOLFIRINOX – Online First – Springer.

Chemotherapy-Induced Amenorrhea in Patients With Breast Cancer With a BRCA1 or BRCA2 Mutation

Age at treatment and use of tamoxifen are important predictors of chemotherapy-induced amenorrhea in women who carry a BRCA1 or BRCA2 mutation. The risk of induced long-term amenorrhea does not seem to be greater among mutation carriers than among women who do not carry a mutation.

via Chemotherapy-Induced Amenorrhea in Patients With Breast Cancer With a BRCA1 or BRCA2 Mutation.

Emergency management of dyspnea in dying pat… [Emerg Med Pract. 2013] – PubMed – NCBI

Opioids are the most effective and widely studied agents available for palliation of dyspnea in this population, while adjuvant therapies such as oxygen, noninvasive positive pressure ventilation, and fans may also play a role. Other medications (eg, benzodiazepines and low-dose ketamine) may also be useful in select patients. The early involvement of palliative medicine specialists and/or hospice services for dying patients can facilitate optimal symptom management and transitions of care.

via Emergency management of dyspnea in dying pat… [Emerg Med Pract. 2013] – PubMed – NCBI.

The efficacy of nonestrogenic therapy to hot flashes in cancer patients under hormone manipulation therapy: a systematic review and meta-analysis – Online First – Springer

Venlafaxine/gabapentin significantly improved hot flashes in cancer patients under hormone manipulation therapies.

via The efficacy of nonestrogenic therapy to hot flashes in cancer patients under hormone manipulation therapy: a systematic review and meta-analysis – Online First – Springer.

Journal of rheumatology, Clinical and Experimental Rheumatology, Submission on line

Pruritus is a common complaint in systemic sclerosis (SSc) and impairs patients` quality of life. Little is known about the pathogenesis of itch in SSc, but complex and multi-factorial mechanisms of itch are appreciated in many chronic diseases. This review discusses the putative mechanisms of the pathogenesis of itch to better understand the mechanisms that may be relevant to pruritus in SSc. It discusses possible therapeutics in the context of this complex pathogenesis.

via Journal of rheumatology, Clinical and Experimental Rheumatology, Submission on line.