Effects of Chemotherapy on Survival of Elderly Patients with… : Journal of Thoracic Oncology

Statistically significant differences in the receipt of chemotherapy exist among elderly patients with SCLC. Chemotherapy is associated with a greater than 6-month improvement in median survival among elderly patients with SCLC, even in patients over the age of 80 years.

via Effects of Chemotherapy on Survival of Elderly Patients with… : Journal of Thoracic Oncology.

Access : The 22|[sol]|11 Risk Prediction Model: A Validated Model for Predicting 30-Day Mortality in Patients With Cirrhosis and Spontaneous Bacterial Peritonitis : The American Journal of Gastroenterology

In cirrhotic patients with SBP receiving standard therapy, MELD score ≥22 and peripheral blood leukocyte count ≥11×109 cells/l are validated independent predictors of mortality. The mortality in a patient without either poor prognostic variable is ≤10% and with both variables is ≥50%. Trials aiming to reduce mortality should target patients in the moderate-risk to high-risk groups.

via Access : The 22|[sol]|11 Risk Prediction Model: A Validated Model for Predicting 30-Day Mortality in Patients With Cirrhosis and Spontaneous Bacterial Peritonitis : The American Journal of Gastroenterology.

Phase Angle, Frailty and Mortality in Older Adults – Online First – Springer

Narrow phase angle is associated with frailty and mortality independent of age and comorbidity.

via Phase Angle, Frailty and Mortality in Older Adults – Online First – Springer.

The Dangers of Loneliness: Findings from a Study among Appalachian Elders | Off the Charts

Writing for AJN in 1955, Hildegard Peplau described the complexities of loneliness, observing that “often loneliness is not felt; instead the person has a feeling of unexplained dread, of desperation, or extreme restlessness.”  Fast-forward to 2009: nurse researchers Laurie Theeke and Jennifer Mallow wanted to better understand the health implications of loneliness, and decided to conduct a study.

via The Dangers of Loneliness: Findings from a Study among Appalachian Elders | Off the Charts.

Leukemia – Survival and prognosis among 1545 patients with contemporary polycythemia vera: an international study

Considering patients from the center with the most mature follow-up information (n=337 with 44% of patients followed to death), median survival (14.1 years) was significantly worse than that of the age- and sex-matched US population (P<0.001). In multivariable analysis, survival for the entire study cohort (n=1545) was adversely affected by older age, leukocytosis, venous thrombosis and abnormal karyotype; a prognostic model that included the first three parameters delineated risk groups with median survivals of 10.9–27.8 years (hazard ratio (HR), 10.7; 95% confidence interval (CI): 7.7–15.0).

via Leukemia – Survival and prognosis among 1545 patients with contemporary polycythemia vera: an international study.

The Median Informs the Message: Accuracy of Individualized Scenarios for Survival Time Based on Oncologists’ Estimates

Conclusion Oncologists’ estimates of survival time were relatively well-calibrated, moderately discriminative, independently associated with observed survival, and a reasonable basis for estimating worst-case, typical, and best-case scenarios for survival.

via The Median Informs the Message: Accuracy of Individualized Scenarios for Survival Time Based on Oncologists’ Estimates.

Access : Critical weight loss is a major prognostic indicator for disease-specific survival in patients with head and neck cancer receiving radiotherapy : British Journal of Cancer

Weight loss both before and during radiotherapy are important prognostic indicators for 5-year DSS in HNC patients. Randomised studies into the prognostic effect of nutritional intervention are needed.

via Access : Critical weight loss is a major prognostic indicator for disease-specific survival in patients with head and neck cancer receiving radiotherapy : British Journal of Cancer.

Access : Radiation-induced bowel injury: the impact of radiotherapy on survivorship after treatment for gynaecological cancers : British Journal of Cancer

Women with cervical cancer are younger and appear to suffer more severe symptoms of late bowel toxicity, whereas women treated for endometrial cancer suffer milder more chronic disease. The impact of radiation-induced bowel injury and the effect on cancer survivorship warrants further research into investigation of predictors of severe late toxicity.

via Access : Radiation-induced bowel injury: the impact of radiotherapy on survivorship after treatment for gynaecological cancers : British Journal of Cancer.

Access : Inconsistencies in methodologies of calculating expectation of life : Spinal Cord

Shavelle et al.1 recently wrote to Spinal Cord with a re-calculation of the life expectancies in the paper of the current authors (Middleton et al.2).

via Access : Inconsistencies in methodologies of calculating expectation of life : Spinal Cord.

The modified Glasgow Prognostic Score (mGPS) is a good predictor of indication for palliative bypass surgery in patients with unresectable pancreatic and biliary cancers – Online First – Springer

The mGPS is useful for predicting survival after surgical decompression due to gastrointestinal obstruction in patients with unresectable pancreatic and biliary cancers. Patients with a poor mGPS may not be indicated for palliative bypass surgery.

via The modified Glasgow Prognostic Score (mGPS) is a good predictor of indication for palliative bypass surgery in patients with unresectable pancreatic and biliary cancers – Online First – Springer.