Topical administration of anesthetics and analgesics can allow for the efficient, painless delivery of medications that may reduce systemic side effects associated with the medication while providing clinical advantages over injected or oral administration for the same clinical situation. Topical administration of nonsteroidal anti-inflammatory drugs (NSAIDs), lidocaine, capsaicin, and other agents is useful for a range of conditions including acute and chronic musculoskeletal pain.
People with diabetes have a 12-25% lifetime risk of developing a foot ulceration, while about 6% of people with diabetes have had foot ulceration in the UK. Diabetic foot ulcers (DFUs) have been associated with higher mortality and reduced quality of life.
The addition of lidocaine 5 % patches is effective in the short term for the treatment of neuropathic cancer pain accompanied by allodynia, whether deriving from a painful scar or chest wall tumor. These findings need to be confirmed by randomized controlled trials with larger samples.
Conclusion Rapid relief of symptoms at end of life is essential. Chlorpromazine in PLO gel may not be an effective treatment option since blood levels were undetectable at 1, 2, and 4 hours after topical application.
Qutenza superiority was demonstrated for both PHN and HIV-AN patients for the primary end point and the end point proportion of 30% pain reduction response, and for PHN patients for the end point of proportion of 50% pain reduction response. These results confirm that Qutenza is effective for the treatment of both PHN and HIV-AN compared to low-dose control patch.
Cooling the skin to 20°C reliably prevents the pain from capsaicin 8% patch application whereas EMLA does not. ENFD reduction is not inhibited by cooling.
Treatment with betamethasone cream is more efficient than moisturizers for the control of acute RT dermatitis in patients treated with adjuvant RT for breast cancer.
via A potent steroid cream is superior to emollients in reducing acute radiation dermatitis in breast cancer patients treated with adjuvant radiotherapy. A randomised study of betamethasone versus two moisturizing creams.
How are topical opioids used to manage painful cutaneous lesions in palliative care? A critical review
This study has been completed.