Chronic obstructive pulmonary disease and exacerbations: Patient insights from the global Hidden Depths of COPD survey – Springer

To reduce the adverse effects of COPD on patients’ quality of life and address their fears for the future, we need better patient education and improved prevention and treatment of exacerbations.

via Chronic obstructive pulmonary disease and exacerbations: Patient insights from the global Hidden Depths of COPD survey – Springer.

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CHEST Journal | Article

This longitudinal study in a real-world COPD population that carefully minimized misclassification of exacerbations and the influence of confounding did not show an association of 25-hydroxyvitamin D with exacerbations and mortality.

via CHEST Journal | Article.

The effect of positive expiratory pressure (PEP) therapy on symptoms, quality of life and incidence of re-exacerbation in patients with acute exacerbations of chronic obstructive pulmonary disease: a multicentre, randomised controlled trial — Osadnik et al. — Thorax

We found no evidence that PEP therapy during AECOPD improves important short-term or long-term outcomes. There does not appear to be a routine role for PEP therapy in the management of such individuals.

via The effect of positive expiratory pressure (PEP) therapy on symptoms, quality of life and incidence of re-exacerbation in patients with acute exacerbations of chronic obstructive pulmonary disease: a multicentre, randomised controlled trial — Osadnik et al. — Thorax.

CHEST Journal | Article

Conclusions:  In a longitudinal multicenter population of adults with CF, clinical variables such as FEV1, exacerbation frequency, and weight were correlated with related CFQ-R subscales. For the population as a whole, the physical domains of CFQ-R, such as respiratory symptoms, were stable. In contrast, population changes in several psychosocial domains of CFQ-R suggest that differentiating between the physical and the psychosocial trajectories in health among adults with CF is critical in evaluating patient-reported outcomes.

via CHEST Journal | Article.

BMC Pulmonary Medicine | Abstract | Chronic obstructive pulmonary disease and exacerbations: Patient insights from the global Hidden Depths of COPD survey

To reduce the adverse effects of COPD on patients’ quality of life and address their fears for the future, we need better patient education and improved prevention and treatment of exacerbations.

via BMC Pulmonary Medicine | Abstract | Chronic obstructive pulmonary disease and exacerbations: Patient insights from the global Hidden Depths of COPD survey.

A meta-analysis on the prophylactic use of macrolide antibiotics for the prevention of disease exacerbations in patients with Chronic Obstructive Pulmonary Disease

Prophylactic macrolides are an effective approach for reducing incident COPD exacerbations. There were several limitations to this study including a lack of consistent adverse event reporting and some degree of clinical and statistical heterogeneity between studies.

via A meta-analysis on the prophylactic use of macrolide antibiotics for the prevention of disease exacerbations in patients with Chronic Obstructive Pulmonary Disease.

A post hoc pooled analysis of exacerbations among US participants in randomized controlled trials of tiotropium

Tiotropium significantly reduced the risk and rates of exacerbations and hospitalizations among US patients with COPD.

via A post hoc pooled analysis of exacerbations among US participants in randomized controlled trials of tiotropium.

Pulmonary rehabilitation following hospitalisation for acute exacerbation of COPD: referrals, uptake and adherence — Jones et al. — Thorax

Despite the strong evidence base, there are poor referral and uptake rates for early outpatient PR following hospitalisation for AECOPD, with only a small proportion of the intended target population receiving this intervention.

via Pulmonary rehabilitation following hospitalisation for acute exacerbation of COPD: referrals, uptake and adherence — Jones et al. — Thorax.

A cohort study of mortality predictors in patients with acute exacerbation of chronic fibrosing interstitial pneumonia — Usui et al. 3 (7) — BMJ Open

Distinct survival curves documented by stratification according to the presence or absence of SIRS and CLE may provide basic information for a rational management strategy for patients with AE of CFIP on admission.

via A cohort study of mortality predictors in patients with acute exacerbation of chronic fibrosing interstitial pneumonia — Usui et al. 3 (7) — BMJ Open.

N-Acetylcysteine for Treating Patients with COPD — A Randomized Trial – NEJM Journal Watch

The drug improved airway mechanics and prevented recurrent exacerbations among patients with chronic obstructive pulmonary disease.

via N-Acetylcysteine for Treating Patients with COPD — A Randomized Trial – NEJM Journal Watch.