Safety and Efficacy of Daptomycin as First-Line Treatment for Complicated Skin and Soft Tissue Infections in Elderly Patients: An Open-Label, Multicentre, Randomized Phase IIIb Trial – Online First – Springer

In elderly patients, for whom data were previously limited, the efficacy and safety of daptomycin have been confirmed, including for infections caused by S. aureus, regardless of methicillin susceptibility.

via Safety and Efficacy of Daptomycin as First-Line Treatment for Complicated Skin and Soft Tissue Infections in Elderly Patients: An Open-Label, Multicentre, Randomized Phase IIIb Trial – Online First – Springer.

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A meta-analysis on the prophylactic use of macrolide antibiotics for the prevention of disease exacerbations in patients with Chronic Obstructive Pulmonary Disease

Prophylactic macrolides are an effective approach for reducing incident COPD exacerbations. There were several limitations to this study including a lack of consistent adverse event reporting and some degree of clinical and statistical heterogeneity between studies.

via A meta-analysis on the prophylactic use of macrolide antibiotics for the prevention of disease exacerbations in patients with Chronic Obstructive Pulmonary Disease.

EWMA Document: Antimicrobials and Non-healing Wounds – Evidence, controversies and suggestions

Non-healing wounds are a significant

problem for health-care systems

worldwide. In the industrialised world,

almost 1-1.5% of the population will have a

problem wound at any one time. Furthermore,

wound management is expensive; in Europe,

the average cost per episode is 6650 euros for leg

ulcers and 10 000 euros for foot ulcers, and wound

management accounts for 2-4% of health-care

budgets. These figures are expected to

rise along with an increased elderly and

diabetic population

via EWMA Document: Antimicrobials and Non-healing Wounds – Evidence, controversies and suggestions.

Probiotics Not Warranted for Seniors Taking Antibiotics: Study: MedlinePlus

This study included nearly 3,000 hospital patients, aged 65 and older, in Great Britain who had been prescribed one or more antibiotics. About half of the patients took one probiotic capsule a day for 21 days, while the other patients took a placebo.

via Probiotics Not Warranted for Seniors Taking Antibiotics: Study: MedlinePlus.

Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): a randomised, double-blind, placebo-controlled, multicentre trial : The Lancet

We identified no evidence that a multistrain preparation of lactobacilli and bifidobacteria was effective in prevention of AAD or CDD. An improved understanding of the pathophysiology of AAD is needed to guide future studies.

via Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): a randomised, double-blind, placebo-controlled, multicentre trial : The Lancet.

Critical Care | Abstract | Diarrhoea in the intensive care unit: respective contribution of feeding and antibiotics

Diarrhoea incidence during the first two weeks in a mixed population of patients in a tertiary ICU is 14%. Diarrhoea risk factors are EN covering >60% of energy target, use of antibiotics and antifungal drugs. The combination of EN covering >60% of energy target with antibiotics or antifungal drugs increases the incidence of diarrhoea.

via Critical Care | Abstract | Diarrhoea in the intensive care unit: respective contribution of feeding and antibiotics.

Should we give long-term macrolide therapy for COPD? — Albert — Thorax

The letter submitted by Crosbie and Woodhead1 pertaining to our study of azithromycin for prevention of acute chronic obstructive pulmonary disease (COPD) exacerbations2 contains a number of errors and misconceptions.

via Should we give long-term macrolide therapy for COPD? — Albert — Thorax.

Excess risk of Clostridium difficile inf… [Support Care Cancer. 2013] – PubMed – NCBI

After adjustment for antibiotic use, ovarian cancer patients are not at excess risk of CDI. Additional studies are needed to understand the patterns of broad-spectrum antibiotic prescription for ovarian cancer patients leading to increased exposure. If feasible, reduction of this exposure may decrease morbidity in this population.

via Excess risk of Clostridium difficile inf… [Support Care Cancer. 2013] – PubMed – NCBI.

Antibiotics for Uncomplicated Severe Malnutrition — NEJM

Trehan et al. (Jan. 31 issue)1 found that amoxicillin or cefdinir improved recovery from severe malnutrition among children in Malawi. The hypothesized reasons for their effectiveness include an underlying immunodeficiency related to malnutrition.1,2 However, although a major cause of immunodeficiency in Malawi is the human immunodeficiency virus (HIV), 68% of enrolled children were not tested for HIV; among those tested, 22% had HIV infection.

via Antibiotics for Uncomplicated Severe Malnutrition — NEJM.

A meta-analysis on the prophylactic use of macrolide antibiotics for the prevention of disease exacerbations in patients with Chronic Obstructive Pulmonary Disease

Prophylactic macrolides are an effective approach for reducing incident COPD exacerbations. There were several limitations to this study including a lack of consistent adverse event reporting and some degree of clinical and statistical heterogeneity between studies.

via A meta-analysis on the prophylactic use of macrolide antibiotics for the prevention of disease exacerbations in patients with Chronic Obstructive Pulmonary Disease.